Publications

HOMAGE is a 6-year European research network (Collaborative Project) supported by the European Commission under the Health Cooperation Work Programme of the 7th Framework Programme, under the Grant Agreement n°305507

Publications

Editorial board

Stratifying Risk using a Bio-marker in Patients with Type-2 Diabetes Mellitus by Prof John GF Cleland

DYDA strudy findings: HbA1c a potential biomarker predictive of cardiovascular eventsby Prof Roberto Latini

HOMAGE publications

WP1

2016

Ferreira J et al. Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC MED 2016 Nov 10;14(1):181

Sandra Sanders-van Wijk et al. Galectin-3 plasma concentrations for prediction of treatment response to beta-blockade and blockade of the renin-angiotensin-aldosterone system in patients with heart failure and reduced ejection fraction: A derivationvalidation. Clinical Chemistry vol.62 Issue 4. April 2016

2013

Eschalier R et al. Extracellular Matrix Turnover Biomarkers Predict Long-Term Left Ventricular Remodeling After Myocardial Infarction Insights From the REVE-2 Study. Circ Heart Fail. 2013 Nov;6(6):1199-205.

WP2

2018

Ferreira JP et al. Echocardiographic diastolic function evolution in patients with an anterior Q-wave myocardial infarction: insights from the REVE-2 study. ESC Heart Fail. 2019 Feb;6(1):70-79.

Masson S et al. Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure. Eur J Heart Fail. 2018 Jan;20(1):78-85.

Gallagher J et al. B-Type Natriuretic Peptide and Ventricular Dysfunction in the Prediction of Cardiovascular Events and Death in Hypertension. Am J Hypertens. 2018 Jan 12;31(2):228-234.

2017

Currie G and Delles C. The Future of "Omics" in Hypertension. Can J Cardiol. 2017 May;33(5):601-610.

2016

Sanders-van Wijk S et al. Interaction of Galectin-3 Concentrations with the Treatment Effects of β-Blockers and RAS Blockade in Patients with Systolic Heart Failure: A Derivation-Validation Study from TIME-CHF and GISSI-HF. Clin Chem. 2016 Apr;62(4):605-16.

Ferreira JP et al. Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Med. 2016 Nov 10;14(1):181

Gu YM et al. Renal glomerular dysfunction in relation to retinal anteriolar narrowing and high pulse pressure in seniors. Hypertens Res. 2016 Mar;39(3):138-43.

Judita Knez et al. Correlates of peripheral blood mitochondrial DNA content in a general population. Am J Epidemiol. 2016 Jan 15; 183(2): 138–146.

Huerta A et al. Association of cystatin C with heart failure with preserved ejection fraction in elderly hypertensive patients. Potential role of altered collagen metabolism. J Hypertens. 2016 Jan;34(1):130-8

López B et al. Myocardial collagen cross-linking is associated with hospitalization for heart failure in patients with hypertensive heart failure. Potential usefulness of a circulating biomarker of collagen cross-linking. J Am Coll Cardiol. 2016 Jan 26;67(3):251-60.

2014

Hazebroek MR et al. Diagnostic approach of myocarditis: strike the golden mean. Neth Heart J. 2014 Feb;22(2):80-4.

Hohl M et al. Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research. Eur J Heart Fail. 2014 Jan;16(1):6-14.

Gemma Currie and Christian Delles Proteinuria and its relation to cardiovascular disease. Int J Nephrol Renovasc Dis. 2014; 7: 13–24.

2013

Lucas N. L. Van Aelst et al. MicroRNAs as Biomarkers for Ischemic Heart Disease. Journal of Cardiovascular Translational Research August 2013, Volume 6, Issue 4, pp 458–470

WP3

2019

Ristagno G et al. Pentraxin 3 in cardiovascular disease. Front Immunol. in press 2019.

John Cleland et al. The year in cardiology 2018: heart failure. Eur Heart J. 2019 Feb 21;40(8):651-661

2018

Rosello Xavier et al. Impact of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with heart failure and left-ventricular systolic dysfunction: an individual patient-level meta-analysis of three randomized-controlled trials. Clin Res Cardiol. 2018 Sep 27

Ferreira Joao et al. Individualizing treatment choices in the systolic blood pressure intervention trial. J Hypertens. 2018 Feb;36(2):428-435

Masson S et al. Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure JAHA. Eur J Heart Fail. 2018 Jan;20(1):78-85.

2017

Jacobs L et al. The Heart “OMics” in AGEing (HOMAGE) investigators. Risk for Incident Heart Failure: A Subject‐Level Meta‐Analysis From the Heart “OMics” in AGEing (HOMAGE) Study. JAHA. 2017 May 2. PubMed

Pitt B et al. Mineralocorticoid receptor antagonists in patients with heart failure: current experience and future perspectives. Eur Heart J Cardiovasc Pharmacother. 2017 Jan;3(1):48-57.

2016

Ferreira JP et al.; Heart ‘OMics’ in AGEing (HOMAGE) initiative and the High-Risk Myocardial Infarction database initiative. Heart ‘OMics’ in AGEing (HOMAGE) initiative and the High-Risk Myocardial Infarction database initiative. Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BioMed Central. 2016 Nov 10.

Sanders-van Wijk S et al.; TIME-CHF Investigators and the GISSI-HF Investigators. Interaction of Galectin-3 Concentrations with the Treatment Effects of β-Blockers and RAS Blockade in Patients with Systolic Heart Failure: A Derivation-Validation Study from TIME-CHF and GISSI-HF. Clin Chem. 2016 Apr

WP4

2016

Ward A. Heggermont et al. Metabolic support for the heart: complementary therapy for heart failure? European Journal of Heart Failure 18(12) October 2016

Summer, G et al. The Network Library: a framework to rapidly integrate network biology resources. Bioinformatics, Volume 32, Issue 17, 1 September 2016, Pages i473–i478

L. N. L. Van Aelst et al. RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection. Am J Transplant. 2016 Jan; 16(1): 99–110

2015

Seronde MF et al. Circulating microRNAs and Outcome in Patients with Acute Heart Failure. PLoS One. 2015 Nov 18;10(11):e0142237.

Lemesle G et al. Multimarker proteomic profiling for the prediction of cardiovascular mortality in patients with chronic heart failure. PLoS One. 2015 Apr 23;10(4):e0119265

Dubois-Deruy E et al. Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure. Cardiovasc Res. 2015 Jul 1;107(1):56-65

Pinet F. et al. [Potential of non-coding RNA as biomarkers in heart failure] Medecine sciences: 31(8-9):770-776 · September 2015

Ho CY et al. Diltiazem treatment for pre-Clinical hypertrophic cardiomyopathy sarcomere mutation carriers: A pilot randomized trial to modify disease expression. JACC Heart Fail. 2015 Feb;3(2):180-8.

Ledwidge MT et al. Cost-effectiveness of natriuretic peptide-based screening and collaborative care: a report from the STOP-HF (St Vincent's Screening TO Prevent Heart Failure) study. Eur J Heart Fail. 2015 Jul;17(7):672-9.

James S et al. Life expectancy for community-based patients with heart failure from time of diagnosis. Int J Cardiol. 2015 Jan 15;178:268-74.

G. Murtagh et al. Importance of risk factor management in diabetic patients and reduction in Stage B heart failure. An International Journal of Medicine, Volume 108, Issue 4, 1 April 2015, Pages 307–314.

Liu YP et al. Inactive matrix Gla protein is causally related to adverse health outcomes : a Mendelian randomization study in a Flemish population. Hypertension. 2015 Feb;65(2):463-70.

Olivi L et al. PEAR1 is not a human hypertension-susceptibility gene. Blood Press. 2015 Feb;24(1):61-4.

Olivi L et al. The - 665 C>T polymorphism in the eNOS gene predicts cardiovascular mortality and morbidity in white Europeans . J Hum Hypertens. 2015 Mar;29(3):167-72.

Kuznetsova T et al. Doppler indexes of left ventricular systolic and diastolic flow and central pulse pressure in relatin to renal resistive index. Am J Hypertens. 2015 Apr;28(4):535-45.

Gu YM et al. Characteristics and determinants of the sublingual microcirculation in populations of different ethnicity. Hypertension. 2015 May;65(5):993-1001.

Ravassa S et al. Biomarkers of cardiomyocyte injury and stress identify left atria and left ventricular remodelling and dysfunction : a population-based study. Int J Cardiol. 2015 Apr 15;185:177-85.

Kuznetsova T et al. Longitudinal changes in left ventricular diastolic function in a general population. Circ Cardiovasc Imaging. 2015 Apr;8(4). pii: e002882.

Zhang ZY et al.Urinary proteome and systolic blood pressure as predictors of 5-year cardiovasular and cardiac outcomes in a general population. Hypertension. 2015 Jul;66(1):52-60.

Pivin E et al. Inactive matrix Gla-protein is associated with arterial stiffness in an adult population-based study. Hypertension. 2015 Jul;66(1):85-92.

Wen-Yi Yang et al. Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population.
BMC Genetics 2015 16:116

Hazebroek MR et al. Prognostic Relevance of Gene-Environment Interactions in Patients With Dilated Cardiomyopathy: Applying the MOGE(S) Classification. J Am Coll Cardiol. 2015 Sep 22;66(12):1313-23.

Ravassa S et al. Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus: a pilot study. Free Radic Biol Med. 2015 Apr;81:1-12.

Ravassa S et al. Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study. Int J Cardiol. 2015 Apr 15;185:177-85

2014

Eschalier R. et al. Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity. Hypertension. 2014 Apr;63(4):740-6.

Jaguszewski M et al. A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction. Eur Heart J. 2014 Apr;35(15):999-1006

Kumarswamy R et al. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ Res. 2014 May 9;114(10):1569-75.

Morley-Smith AC et al. Circulating microRNAs for predicting and monitoring response to mechanical circulatory support from a left ventricular assist device. Eur J Heart Fail. 2014 Aug;16(8):871-9

WP5

2019

Ravassa S et al. A combination of collagen type I-related circulating biomarkers is associated with atrial fibrillation. Journal of the American College of Cardiology. In press 2019

Martínez-Martínez E et al. Cardiotrophin-1-galectin-3 axis in cardiac fibrosis and inflammation. Mechanistic insights and clinical implications. Hypertension. 2019 Mar;73(3):602-611

Cauwenberghs N et al. Circulating biomarkers predicting longitudinal changes in left ventricular structure and function in a general population. J Am Heart Assoc. 2019 Jan 22;8(2):e010430.

2018

C Delles et al. Utilizing proteomics to understand and define hypertension: where are we and where do we go? Expert Rev Proteomics. 2018; 15(7): 581–592.

E Sliz et al. Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation. 2018 Nov 27;138(22):2499-2512

De Gonzalo-Calvo D et al. Circulating non-coding RNAs as biomarkers to predict and monitor the response to exercise: chances and hurdles. Eur Heart J. 2018 Oct 7;39(38):3552.

de Gonzalo-Calvo D et al. Circulating miR-1254 predicts ventricular remodeling in patients with ST-Segment-Elevation Myocardial Infarction: A cardiovascular magnetic resonance study. Sci Rep. 2018 Oct 11;8(1):15115

Huang QF et al. Urinary proteomic signatures associated with beta-blockade and heart rate in heart transplant recipients. PLoS One. 2018 Sep 24;13(9):e0204439.

Ravassa S et al. Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial. Eur J Heart Fail. 2018 Sep;20(9):1290-1299.

Magalhães P et al. Comparison of Urine and Plasma Peptidome Indicates Selectivity in Renal Peptide Handling. Proteomics Clin Appl. 2018 Sep;12(5):e1700163.

Ferreira JP et al. Potential Spironolactone effects on collagen metabolism biomarkers in patients with uncontrolled blood pressure. Heart. 2018 Aug 18. pii: heartjnl-2018-313182.

Turkieh A et al. Expression and Implication of Clusterin in Left Ventricular Remodeling After Myocardial Infarction. Circ Heart Fail. 2018 Jun;11(6):e004838.

Zhang ZY et al. Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction. J Am Soc Hypertens. 2018 Jun;12(6):438-447.e4.

G Currie et al. Precision Medicine and Personalized Medicine in Cardiovascular Disease. Adv Exp Med Biol. 2018;1065:589-605

de Gonzalo-Calvo D et al. Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine? Eur Heart J. 2018 Apr 24.

C Delles et al. Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997. Eur J Heart Fail. 2018 Apr;20(4):663-673.

Huang QF et al. Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study. Transplant Direct. 2018 Apr 23;4(5):e346.

C Delles et al. Sex differences in hypertension and other cardiovascular diseases. Journal of Hypertension. 36(4):768–770, APR 2018

Frantz S et al. The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. Eur J Heart Fail. 2018 Mar;20(3):445-459.

Rossignol patrick et al. Spironolactone and Resistant Hypertension in Heart Failure With Preserved Ejection Fraction. Am J Hypertens. 2018 Mar 10;31(4):407-414

Ferreira Joao et al. Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis. ESC Heart Fail. 2018 Feb;5(1):139-148.

Treibel TA et al. Reappraising myocardial fibrosis in severe aortic stenosis – an invasive and non-invasive study in 133 patients. Eur Heart J. 2018 Feb 21;39(8):699-709.

G Currie et al. Blood pressure targets in the elderly. J Hypertens. 2018 Feb;36(2):234-236.

Treibel TA et al. Prediction of acute coronary syndromes by urinary proteome analysis. European Heart Journal, Volume 39, Issue 8, 21 February 2018, Pages 699–709.

Lindhardt M et al. Predicting albuminuria response to spironolactone treatment with urinary proteomics in patients with type 2 diabetes and hypertension. Nephrol Dial Transplant. 2018 Feb 1;33(2):296-303.

Ferreira Joao et al. Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study. Clin Res Cardiol. 2018 Jan;107(1):49-59

2017

Viereck J and Thum T. Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury. Circ Res. 2017 Jan 20

Pinet F. et al. Integrative network analysis reveals time-dependent molecular events underlying left ventricular remodeling in post-myocardial infarction patients. Biochim Biophys Acta. 2017 Jun;1863(6):1445-1453.

Jacobs L et al.; Heart “OMics” in AGEing (HOMAGE) investigators. Risk for Incident Heart Failure: A Subject-Level Meta-Analysis From the Heart "OMics" in AGEing (HOMAGE) Study. J Am Heart Assoc. 2017 May 2;6(5).

Dubois-Deruy E et al. MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure. Scientific Reports 7: 4747

Löfsjögård J et al. Prediction of acute coronary syndromes by urinary proteome analysis. Am J Cardiol. 2017 Jun 15;119(12):2042-2048.

Htun NM et al. Prediction of acute coronary syndromes by urinary proteome analysis. PLoS One. 2017 Mar 8;12(3):e0172036.

Pontillo C and Mischak H. Urinary peptide-based classifier CKD273: towards clinical application in chronic kidney disease. Clin Kidney J. 2017 Apr;10(2):192-201

Cherney D et a. The effect of sodium/glucose cotransporter 2 (SGLT2) inhibition on the urinary proteome. PLoS One. 2017 Oct 30;12(10):e0186910.

Pontillo C et a. Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker. Kidney Int Rep. 2017 Nov;2(6):1066-1075.

Krochmal M et al. Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy. Scientific Reports 7: 15160.

Viereck J et al. Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury. Circ Res. 2017 Jan 20;120(2):381-399.

Javier Beaumont et al. MicroRNA-19b is associated with myocardial collagen cross-linking and heart failure in patients with severe aortic stenosis. Sci Rep. 2017; 7: 40696

2016

Rossing K et al. Urinary Proteomics Pilot Study for Biomarker Discovery and Diagnosis in Heart Failure with Reduced Ejection Fraction. PLOS ONE. 2016 Jun 16. PubMed

Zhang et al. Diastolic Left Ventricular Function in Relation to Urinary and Serum Collagen Biomarkers in a General Population. Hypertension. 2016 Dec 13

Gupta SK et al. Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction. J Am Coll Cardiol. 2016 Oct 4

Shashi KumarGupta et al. Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction. Journal of the American College of Cardiology 68(14):1557-1571. October 2016

Currie G et al. Urinary Proteomics for Diagnosis and Monitoring of Diabetic Nephropathy. Curr Diab Rep. 2016 Nov;16(11):104.

Rossing K et al. Urinary Proteomics Pilot Study for Biomarker Discovery and Diagnosis in Heart Failure with Reduced Ejection Fraction. PLoS One. 2016 Jun 16;11(6):e0157167.

Farmakis D et al. Urine proteome analysis in heart failure with reduced ejection fraction complicated by chronic kidney disease: feasibility, and clinical and pathogenetic correlates. Eur J Heart Fail. 2016 Jul;18(7):822-9.

Ulf Neisius et al. Urine proteomics in the diagnosis of stable angina. BMC Cardiovascular Disorders BMC series 2016.

Currie G et al. Use of Biomarkers in the Evaluation and Treatment of Hypertensive Patients. Curr Hypertens Rep. 2016 Jul;18(7):54.

2015

Vodovar N et al. Elevated Plasma B-Type Natriuretic Peptide Concentrations Directly Inhibit Circulating Neprilysin Activity in Heart Failure. JACC Heart Fail. 2015 Aug;3(8):629-36.

López B et al. Galectin-3 and histological, molecular and biochemical aspects of myocardial fibrosis in heart failure of hypertensive origin. Eur J Heart Fail. 2015 Apr;17(4):385-92

López B et al. Circulating biomarkers of myocardial fibrosis: the need for a reappraisal. J Am Coll Cardiol. 2015 Jun 9;65(22):2449-56

Ravassa S et al. Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: A population-based study. Int J Cardiol. 2015 Apr 15;185:177-85.

Zhang ZY et al. Urinary Proteome and Systolic Blood Pressure as Predictors of 5-Year Cardiovascular and Cardiac Outcomes in a General Population. Hypertension. 2015 Jul;66(1):52-60.

Pejchinovski M et al. Capillary zone electrophoresis on-line coupled to mass spectrometry: A perspective application for clinical proteomics. Proteomics Clin Appl. 2015 Jun;9(5-6):453-68

Schanstra JP et al. Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides. J Am Soc Nephrol. 2015 Aug;26(8):1999-2010

2014

Zhang ZY et al. Left ventricular diastolic function in relation to the urinary proteome: A proof-of-concept study in a general population. Int J Cardiol. 2014 Sep

Tomaschitz A et al. Homoarginine, kidney function and cardiovascular mortality risk. Nephrol Dial Transplant. 2014 Mar;29(3):663-71.

Tomaschitz A et al. Interplay between sodium and calcium regulatory hormones: a clinically relevant research field. Hypertension. 2014 Feb;63(2):212-4

Tomaschitz A et al. Aldosterone and parathyroid hormone interactions as mediators of metabolic and cardiovascular disease. Metabolism. 2014 Jan;63(1):20-31

Beaumont J et al. MicroRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β1 up-regulation. Clin Sci (Lond). 2014 Apr;126(7):497-506

López B et al. Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure. Hypertension. 2014 Mar;63(3):483-9.

Jaguszewski M et al. A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction. Eur Heart J. 2014 Apr;35(15):999-1006.

2013

Marie Fertin et al. Serum MMP-8: a novel indicator of left ventricular remodeling and cardiac outcome in patients after acute myocardial infarction. PLoS One. 2013; 8(8): e71280.

López B et al. Osteopontin-mediated myocardial fibrosis in heart failure. A role for lysyl oxidase ? Cardiovasc Res. 2013 Jul 1;99(1):111-20

Ravassa S et al. The activity of circulating dipeptidyl peptidase-4 is associated with subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2013 Oct 7;12:143.

WP6

2019

Kuznetsova T et al. Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling. Echocardiography. 2019 Mar;36(3):458-468

Zhang ZY et al. Urinary Peptidomic Biomarker for Personalized Prevention and Treatment of Diastolic Left Ventricular Dysfunction. Proteomics Clin Appl. 2019 Jan 11:e1800174.

Cauwenberghs N et al. Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General Population. J Am Heart Assoc. 2019 Jan 22;8(2):e010430.

Yu CG et al. Neurocognitive function in relation to blood lead among young men prior to chronic occupational exposure. Scand J Work Environ Health. 2019 Jan 11. pii: 3798.

Zhang ZY et al. Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study. Eur J Prev Cardiol. 2019 Jan;26(1):22-32.

2018

Yang WY et al. Evidence-based proposal for the number of ambulatory readings required for assessing blood pressure level in research settings: an analysis of the IDACO database. Blood Press. 2018 Dec;27(6):341-350.

Wei FF et al. Resistant hypertension. Kardiol Pol. 2018;76(7):1031-1042.

Zhang ZY et al. Branched-Chain Amino Acids as Critical Switches in Health and Disease. Hypertension. 2018 Nov;72(5):1012-1022.

Wei FF et al. Inactive matrix Gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans. Sci Rep. 2018 Oct 10;8(1):15088.

Huang QF et al. Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients. PLoS One. 2018 Sep 24;13(9):e0204439.

Blerim M et al. Renal function in relation to low-level environmental lead exposure. Nephrol Dial Transplant. 2018 Aug 27.

Cheng YB et al. Association of pulse wave velocity with single nucleotide polymorphisms related to parathyroid hormone. Blood Press. 2018 Aug;27(4):222-230

João Pedro Ferreira et al. Potential spironolactone effects on collagen metabolism biomarkers in patients with uncontrolled blood pressure. Heart (British Cardiac Society) 105(4):heartjnl-2018-313182 · August 2018.

Tikhonoff V et al. Ambulatory blood pressure and long-term risk for atrial fibrillation. Heart. 2018 Aug;104(15):1263-1270.

Ferreira Joao et al. Data-Driven Approach to Identify Subgroups of Heart Failure With Reduced Ejection Fraction Patients With Different Prognoses and Aldosterone Antagonist Response Patterns. Circ Heart Fail. 2018 Jul;11(7):e004926.

Huang QF et al. Urinary peptidomic biomarkers of renal function in heart transplant recipients. Nephrol Dial Transplant. 2018 Jul 2.

Wei FF et al. Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting deterioration of renal function in the general population. Nephrol Dial Transplant. 2018 Jul 1;33(7):1122-1128.

Wei FF et al. Diagnosis and management of resistant hypertension: state of the art. Nat Rev Nephrol. 2018 Jul;14(7):428-441.

Zhang ZY et al. Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction. J Am Soc Hypertens. 2018 Jun;12(6):438-447.e4.

Martens DS et al. Retinal microcirculation and leukocyte telomere length in the general population. Scientific Reports volume 8, Article number: 7095 (2018 May)

Ferreira Joao et al. Cohort Profile: Rationale and design of the fourth visit of the STANISLAS cohort: a familial longitudinal population-based cohort from the Nancy region of France. Int J Epidemiol. 2018 Apr 1;47(2):395-395j.

Huang QF et al. Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study. Transplant Direct. 2018 Apr 23;4(5):e346

Cauwenberghs N et al. Doppler indexes of left ventricular systolic and diastolic function in relation to haemodynamic load components in a general population. J Hypertens. 2018 Apr;36(4):867-875.

Wei FF et al. Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction. PLoS One. 2018 Mar; 13(3): e0193967.

Lu YC et al. Brachial-ankle pulse wave velocity compared with mean arterial pressure and pulse pressure in risk stratification in a Chinese population. J Hypertens. 2018 Mar;36(3):528-536.

Wei FF et al. Cognition in relation to the retinal microcirculation in children born preterm or at term. Early Hum Dev. 2018 Mar;118:1-7.

Wei FF et al. The risk of nephrolithiasis is causally related to inactive matrix Gla protein, a marker of vitamin K status: a Mendelian randomization study in a Flemish population. Nephrol Dial Transplant. 2018 Mar 1;33(3):514-522.

Feng YM et al. Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population. Nephrol Dial Transplant. 2018 Mar 1;33(3):426-435.

Huang QF et al. Reproducibility of retinal microvascular traits decoded by the Singapore I Vessel Assessment Software across the human age range. Am J Hypertens. 2018 Mar 10;31(4):438-449.

Cauwenberghs N et al. Relation of insulin resistance to longitudinal changes in left ventricular structure and function in a general population. Journal of the American Heart Association. 2018 Mar;7

Yang WY et al. Letter to editor: Blood pressure, hypertension and lead exposure. Environmental Health 2018 Feb 17:16.

Persu A et al. Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis. J Hypertens. 2018 Feb;36(2):221-229.

Wei FF et al. Conventional and ambulatory blood pressure as predictors of diastolic left ventricular function in a Flemish population. J Am Heart Assoc. 2018 Feb 8;7(4). pii: e007868.

Yang WY et al. ECG voltage in relation to peripheral and central ambulatory blood pressure. American Journal of Hypertension, Volume 31, Issue 2, 12 January 2018, Pages 178–187.

Yang WY et al. Association of office and ambulatory blood pressure with blood lead in workers before occupational exposure. J Am Soc Hypertens. 2018 Jan;12(1):14-24.

2017

Yang WY et al. Left ventricular structure and function in relation to environmental exposure to lead and cadmium. J Am Heart Assoc. 2017 Feb 1;6(2).

Raaijmakers A et al. Does extremely low birth weight predispose to low-renin hypertension? Hypertension. 2017 Mar;69(3):443-449.

Juhanoja EP et al. Outcome driven thresholds for increased home blood pressure variability. Hypertension 2017; 69(4):599-607

Kyoko Nomura et al. Renal function in relation to sodium intake: a quantitative review of the literature. Kidney Int. 2017; 92(1):67-78

Fadl Elmula FEM et al. Sham or no sham control: that is the question in trials of renal denervation for resistant hypertension. A systematic meta-analysis. Blood Press. 2017; 26(4):195-203

Wen-Yi Yang et al. PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population. BMC Med Genet. 2017; 18: 45.

Anke Raaijmakers et al. Catch-up growth in the first two years of life in Extremely Low Birth Weight (ELBW) infants is associated with lower body fat in young adolescence. PLoS One. 2017 Mar 9;12(3):e0173349.

Staessen JA et al. Blood pressure measurement anno 2016. Am J Hypertens. 2017 May 1;30(5):453-463.

Jacobs L et al. Results of a randomized controlled pilot trial of intravascular renal denervation for management of treatment-resistant hypertension. Blood Press. 2017 Dec;26(6):321-331.

Melgarejo JD et al. Prevalence, treatment, and control rates of conventional and ambulatory hypertension across 10 populations in 3 continents. Hypertension. 2017 Jul;70(1):50-58.

Augustine N Odili et al. Office and home blood pressures as determinants of electrocardiographic left ventricular hypertrophy among black Nigerians compared with white Flemish. American Journal of Hypertension, Volume 30, Issue 11, 1 November 2017, Pages 1083–1092,

Zhen‐Yu Zhang et al. Novel urinary peptidomic classifier predicts indicent heart failure.
Journal of the American Heart Association. 2017;6:e005432

Wei FF et al. Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting deterioration of renal function in the general population. Nephrol Dial Transplant. 2017 Aug 25.

Ljupcho Efremov et al. Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population. Artery Res. 2017 Sep; 19: 9–17.

Zhang ZY et al. A urinary fragment of Mucin-1 subunit α is a novel biomarker associated with renal dysfunction in the general population. Kidney Int Rep. 2017 Sep;2(5):811-820.

Cheng YB et al. Independent effects of blood pressure and parathyroid hormone on aortic pulse wave velocity in untreated Chinese patients. J Hypertens. 2017 Sep;35(9):1841-1848.

Yang WY et al. Left ventricular function in relation to chronic residential air pollution in a general population. Eur J Prev Cardiol. 2017 Sep;24(13):1416-1428.

Huang QF et al. Urinary proteomics in predicting heart transplantation ourcomes (uPROPHET) – Rationale and database description. PLoS One. 2017 Sep 7;12(9):e0184443.

Asayama K et al. Cardiovascular risk associated with white coat hypertension: con side of the argument. Hypertension. 2017 Oct;70(4):676-682.

Pontillo C et al. A urinary proteome-based classifier for the early detection of decline in glomerular filtration. Nephrol Dial Transplant. 2017 Sep 1;32(9):1510-1516.

Sheng CS et al. Diurnal blood pressure rythmicity in relation to environment and genetic cues in untreated referred patients. Hypertension. 2017 Jan;69(1):128-135. Epub 2016 Nov 7.

Jacobs L et al. Risk score for incident heart failure: a subject-level meta-analysis from the Heart 'Omnics' in AGEing (HOMAGE) database. J Am Heart Assoc. 2017 May 2;6(5). pii: e005231.

2016

Kuznetsova T et al. Additive prognostic value of left ventricular systolic dysfunction in a population-based cohort. Circ Cardiovasc Imaging. 2016 Jul;9(7). pii: e004661.

Knez J et al. Association of left ventricular structure and function with peripheral blood mitochondrial DNA content in a general population. Int J Cardiol. 2016 Jul 1;214:180-8.

Wei FF et al. Conventional and ambulatory blood pressure as predictors of retinal narrowing. Hypertension. 2016 Aug;68(2):511-20.

Zhen-Yu Zhang et al. Diastolic left ventricular function in relation to urinary and serum collagen biomarkers in a general population. PLoS One. 2016; 11(12): e0167582.

Hara A et al. Incidence of nephrolithiasis in relation to environmental exposure to lead and cadmium in a population study. Environ Res. 2016 Feb;145:1-8.

Ying-Mei Feng et al. Insulin resistance in relation to lipids and inflammation in type-2 patients and non-diabetic people. PLoS One. 2016; 11(4): e0153171.

Manunta P et al. Personalized therapy of hypertension: the past and the future. Curr Hypertens Rep. 2016 Mar;18(3):24.

Lu YC et al. Quality control of blood pressure phenotype in the Gaoyou population study. Blood Press. 2016 Jun;25(3):162-8.

Gu YM et al. Renal glomerular dysfunction in relation to retinal anteriolar narrowing and high pulse pressure in seniors. Hypertens Res. 2016 Mar;39(3):138-43.

Wei FF et al. Retinal microvascular diameter, a hypertensive-relaited trait in ECG-gated vs non-gated images analyzed by IVAN and SIVA. Hypertens Res. 2016 Dec;39(12):886-892.

Persu A et al. STK39 and WNK1 are potential hypertension susceptibility genes in the BELHYPGEN cohort. Medicine (Baltimore). 2016 Apr;95(15):e2968.

Boggia J et al. The Diurnal profile of central hemodynamics in a general Uruguayan population. Am J Hypertens. 2016 Jun;29(6):737-46.

Fang-Fei Wei et al. Vitamin K dependent protection of renal function in multi-ethnc population studies. EBioMedicine. 2016 Feb; 4: 162–169.

Fang-Fei Wei et al. Vitamin-K-dependent protection of renal microvasculature: histopathological studies in normal and diseased kidneys. Pulse (Basel). 2016 Sep; 4(2-3): 85–91.

Scheepers LE et al. Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study. J Hypertens. 2016 Nov;34(11):2147-54.

Hara A et al. Incidence of nephrolithiasis in relation to environmental exposure to lead and cadmium in a population study. Environ Res. 2016 Feb;145:1-8.

Boggia J et al. The diurnal profile of central hemodynamics in a general Uruguayan population. Am J Hypertens. 2016 Jun;29(6):737-46.

Lu YC et al. Quality control of blood pressure phenotype in the Gaoyou population study. Blood Press. 2016 Jun;25(3):162-8.

2015

Hara A et al. Blood pressure in relation to environmental lead exposure in the national health and nutrition examination survey 2003 to 2010. Hypertension. 2015 Jan;65(1):62-9.

Franklin SS et al. Masked hypertension : a phenomenon of measurement. Hypertension. 2015 Jan;65(1):16-20.

Stolarz-Skrzypek K et al. Reducing salt intake for prevention of cardiovascular disease times are changing. Adv Chronic Kidney Dis. 2015 Mar;22(2):108-15.

Niiranen TJ et al. Optimal numbers of days for home blood pressure measurement. Am J Hypertens. 2015 May;28(5):595-603

Hara A et al. Study for promotion of health in recycling lead - rationale and design. Blood Press. 2015 Jun;24(3):147-57.

Kei Asayama et al. Prognosis in relation to blood pressure variability: con side of the argument.
Hypertension. 2015;65:1170-1179

Zhang L et al. Strategies for classyfying patients base on office, home and ambulatory blood pressure measurement. Hypertension. 2015 Jun;65(6):1258-65.

Hazebroek MR et al. Prevalence and prognostic relevance of cardiac involvement in ANCA-associated vasculitis : eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis. Int J Cardiol. 2015 Nov 15;199:170-9

Fadl Elmula FE et al. Meta-analysis of randomized controlled trials of renal denervation in treatment-resistant hypertension. Blood Press. 2015;24(5):263-74.

Raaijmakers A et al. Design and feasibility of "PREMATurity as predictor of children's Cardiovascular-renal Health" (PREMATCH) : a pilot study. Blood Press. 2015;24(5):275-83.

Lucas S. Aparicio et al. Defining thresholds for home blood pressure monitoring in octogenarians.
Hypertension. 2015;HYPERTENSIONAHA.115.05800

Winkler TW et al. The influence of age and sex on genetic associations with adult body size and shape : a large-scale genome-wide interaction study. PLoS Genet. 2015 Oct 1;11(10):e1005378.

2014

Jacobs L et al. Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. J. Biomed Res.. 2014 Sep 28. PubMed

WP8

2019

de Boer RA et al.Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the committee of translational research of the heart failure association (HFA) of te ESC. Eur J Heart Fail. 2019 Feb 4

2018

Bayés-Genis A et al. ST2 in Heart Failure. Circ Heart Fail. 2018 Dec;11(12):e005582

Maack C et al. Metabolic alterations and therapeutic interventions in heart failure and type 2 diabetes mellitus – a translational research perspective. A state-of-the-art review from the Translational Research Committee of the Heart Failure Association - European Society of Cardiology. Eur Heart J. 2018 Dec 21;39(48):4243-4254

González A et al. Myocardial remodeling in hypertension. Towards a new view of hypertensive heart disease. Hypertension 72(3):549-558. September 2018

Bayes-Genis A et al.Transitioning from usual care to biomarker-based personalized and precision medicine in heart failure: call for action. Eur Heart J. 2018 Aug 7;39(30):2793-2799

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